It is important to consider whether the sample size selected by the Environmental Genome Project will provide sufficient power to discover most alleles relevant to gene-environment interactions.
Moreover environmental health at the local level has become narrowly focused very much defined around regulations and the attendant regulatory debates.
One of the responsibilities faced by the Environmental Genome Project is to provide the science base upon which society can make better informed risk management decisions.
The infrastructure for linking environmental health and public health is not working as well as it should.
We all recognize that in recent decades many important achievements have helped create a cleaner healthier environment yet our national needs in environmental health are not being fully met.
While the Environmental Genome Project does not seek to assign allele frequencies we are aware of the importance of accurate allele frequency estimates for future epidemiologic studies and the large sample sizes such estimates will require.